Relationship between baseline white blood cell count and renal and hepatic function in older patients with acute myeloid leukemia

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Abstract

Background: In a phase III trial, older patients with acute myeloid leukemia (N=485) received decitabine or treatment choice (supportive care or cytarabine). This post hoc analysis examined whether baseline renal and hepatic function and white blood cell (WBC) counts predicted response. Methods: Baseline WBCs and renal and liver function markers were tabulated for responders/nonresponders. Results: Nonresponders had higher mean baseline creatinine (P=0.005). Creatinine data showed no significant between-group differences by treatment within responder category. Conclusions: No relationship was found between baseline WBCs or hepatic function and response. Higher baseline creatinine in nonresponders may not be clinically relevant. © 2013 The Authors.

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Delaunay, J., Mazur, G., Minden, M., Wierzbowska, A., Jones, M. M., Berrak, E., & Kantarjian, H. M. (2014). Relationship between baseline white blood cell count and renal and hepatic function in older patients with acute myeloid leukemia. Leukemia Research Reports, 3(1), 17–20. https://doi.org/10.1016/j.lrr.2013.12.001

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