PST (post-stimulus time) and interval histograms computed from recorded spike trains are related to an average timing characteristics of the spike train. The exact nature of this relationship varies with recording parameters, interfering signals, the histogram bin width, and the duration of the measurement interval. This work describes the conditions under which a PST histogram can serve as an unbiased estimate of the ensemble average of a spike train's intensity and an interval histogram can serve as an unbiased estimate of the probability density function of the interspike intervals. Simulation studies are used to confirm the validity of the theoretical results. As an example of an application, these results are used to analyze recordings of singleunit activity in the eight cranial nerve. © 1978, The Biophysical Society. All rights reserved.
Johnson, D. H. (1978). The relationship of post-stimulus time and interval histograms to the timming characteristics of spike trains. Biophysical Journal, 22(3), 413–430. https://doi.org/10.1016/S0006-3495(78)85496-4