The exact role of the lymphoreticular system in the spread of peripheral prion infections to the central nervous system still needs further elucidation. Against this background, the influence of the regional lymph node (Ln. popliteus) on the pathogenesis of scrapie was monitored in a hamster model of prion infection via the footpad.
Kratzel, C., Krüger, D., & Beekes, M. (2007). Relevance of the regional lymph node in scrapie pathogenesis after peripheral infection of hamsters. BMC Veterinary Research, 3. https://doi.org/10.1186/1746-6148-3-22