The polyphenol resveratrol has anti-inflammatory effects in various cells, tissues, animals and human settings of low-grade inflammation. Psoriasis is a disease of both localized and systemic low-grade inflammation. The Sirtuin1 enzyme thought to mediate the effects of resveratrol is present in skin and resveratrol is known to down regulate NF-κB; an important contributor in the development of psoriasis. Consequently we investigated whether resveratrol has an effect on an Imiquimod induced psoriasis-like skin inflammation in mice and sought to identify candidate genes, pathways and interleukins mediating the effects.
Kjær, T. N., Thorsen, K., Jessen, N., Stenderup, K., & Pedersen, S. B. (2015). Resveratrol ameliorates imiquimod-induced psoriasis-like skin inflammation in mice. PLoS ONE, 10(5). https://doi.org/10.1371/journal.pone.0126599