Bioapatite, the main constituent of mineralized tissue in mammalian bones, is a calcium-phosphate-based mineral that is similar in structure and composition to hydroxyapatite. In this work, the crystallographic structure of bioapatite in human fetuses was investigated by synchrotron radiation x-ray diffraction (XRD) and microdiffraction (μ-XRD) techniques. Rietveld refinement analyses of XRD and μ-XRD data allow for quantitative probing of the structural modifications of bioapatite as functions of the mineralization process and gestational age.
Meneghini, C., Dalconi, M. C., Nuzzo, S., Mobilio, S., & Wenk, R. H. (2003). Rietveld refinement on x-ray diffraction patterns of bioapatite in human fetal bones. Biophysical Journal, 84(3), 2021–2029. https://doi.org/10.1016/S0006-3495(03)75010-3