The purpose of this study was to determine whether levels of interleukin-6 (IL-6) in childhood are related to insulin resistance in adolescence. Further, to explore how fatness and cardiorespiratory fitness ( VO2peak ) moderate this relationship. Methods . 292 nine-year-old children ( n=292 ) were followed for 4 years. Anthropometrics and VO2peak were measured. Fasting blood samples were analyzed for IL-6, insulin, and glucose. Homeostasis model assessment (HOMA-IR) was used as a measure of insulin resistance. Results . For girls but not boys, levels of IL-6 at age 9 yrs correlated with HOMA-IR at age 13 yrs: r=0.223 , P=0.008 . Girls with IL-6 levels within the highest quartile at age 9 yrs had an odds ratio of 3.68 (CI = 1.58–8.57) being in the highest quartile of HOMA-IR four years later. Conclusion . In this cohort, IL-6 levels in childhood were related to insulin resistance in adolescence, but only for girls.
Bugge, A., El-Naaman, B., G. McMurray, R., Froberg, K., Nielsen, C. H., Müller, K., & Andersen, L. B. (2012). Sex differences in the association between level of childhood interleukin-6 and insulin resistance in adolescence. Experimental Diabetes Research, 2012. https://doi.org/10.1155/2012/859186