Background: The mechanisms underlying acute ERK signaling are poorly understood. Results: Feedback influences basal and acutely stimulated ERK responses but does not render signaling kinetics robust to ERK concentration. Conclusion: Acute ERK response kinetics depend on ERK concentration and activation mechanism as well as feedback. Significance: ERK responses to transient stimulation can be gated by ERK concentration, and short-term activation appears distributive rather than processive. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
Perrett, R. M., Fowkes, R. C., Caunt, C. J., Tsaneva-Atanasova, K., Bowsher, C. G., & McArdle, C. A. (2013). Signaling to extracellular signal-regulated kinase from erbb1 kinase and protein kinase c: Feedback, heterogeneity, and gating. Journal of Biological Chemistry, 288(29), 21001–21014. https://doi.org/10.1074/jbc.M113.455345