Simulated microgravity inhibits the genetic expression of interleukin-2 and its receptor in mitogen-activated T lymphocytes

98Citations
Citations of this article
23Readers
Mendeley users who have this article in their library.

Abstract

Experiments conducted in space in the last two decades have shown that T lymphocyte activation in vitro is remarkably reduced in microgravity. The data indicate that a failure of the expression of the interleukin-2 receptor (measured as protein secreted in the supernatant) is responsible of the loss of activity. To test such hypothesis we have studied the genetic expression of interleukin-2 and of its receptor in concanavalin A-activated lymphocytes with the RT-PCR technology. Microgravity conditions were simulated in the fast rotating clinostat and in the random positioning machine. The latter is an instrument introduced recently to study gravitational effects on single cells. Our data clearly show that the expression of both IL-2 and IL-2Rα genes is significantly inhibited in simulated 0xg. Thus full activation is prevented. Copyright (C) 1998 Federation of European Biochemical Societies.

Cite

CITATION STYLE

APA

Walther, I., Pippia, P., Meloni, M. A., Turrini, F., Mannu, F., & Cogoli, A. (1998). Simulated microgravity inhibits the genetic expression of interleukin-2 and its receptor in mitogen-activated T lymphocytes. FEBS Letters, 436(1), 115–118. https://doi.org/10.1016/S0014-5793(98)01107-7

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free