Skewed lung CCR4 to CCR6 CD4 + t cell ratio in Idiopathic Pulmonary Fibrosis is associated with pulmonary function

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© 2016 Adegunsoye, Hrusch, Bonham, Jaffery, Blaine, Sullivan, Churpek, Strek, Noth and Sperling. Rationale: Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal lung disease. While it has been suggested that T cells may contribute to IPF pathogenesis, these studies have focused primarily on T cells outside of the pulmonary interstitium. Thus, the role of T cells in the diseased lung tissue remains unclear. Objective: To identify whether specific CD4 + T cell subsets are differentially represented in lung tissue from patients with IPF. Methods: CD4 + T cell subsets were measured in lung tissue obtained from patients with IPF at the time of lung transplantation, and from age- and gender-matched organ donors with no known lung disease. Subsets were identified by their surface expression of CCR4, CCR6, and CXCR3 chemokine receptors. CD4 + T cell subsets were correlated with measurements of lung function obtained prior to transplantation. Results: Compared to controls, IPF patients had a higher proportion of lung CD4 + T cells, a higher proportion of CCR4 + CD4 + T cells, and a lower proportion of CCR6 + CD4 + T cells. The increase in CCR4 + CD4 + T cells in IPF lung tissue was not due to increased Tregs. Intriguingly, the increase in the ratio of CCR4 + cells to CCR6 + cells correlated significantly with better lung function. Conclusion: Our findings suggest a new paradigm that not all T cell infiltrates in IPF lungs are detrimental, but instead, specialized subsets may actually be protective. Thus, augmentation of the chemokines that recruit protective T cells, while blocking chemokines that recruit detrimental T cells, may constitute a novel approach to IPF therapy.




Adegunsoye, A., Hrusch, C. L., Bonham, C. A., Jaffery, M. R., Blaine, K. M., Sullivan, M., … Sperling, A. I. (2016). Skewed lung CCR4 to CCR6 CD4 + t cell ratio in Idiopathic Pulmonary Fibrosis is associated with pulmonary function. Frontiers in Immunology, 7(NOV).

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