The spindle assembly checkpoint

  • Varetti G
  • Musacchio A
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Abstract

Mitosis, the process of eukaryotic somatic cell division, consists of a series of consecutive, highly regulated events. It leads to the generation of two daughter cells containing identical complements of the genome. When mitosis fails, the daughter cells inherit an abnormal number of chromosomes (aneuploidy). This has dire consequences on cell physiology and might facilitate tumorigenesis. Here, we describe the organization of the spindle assembly checkpoint (SAC), a sophisticated surveillance mechanism that acts in mitosis to ensure the fidelity of chromosome segregation.

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Varetti, G., & Musacchio, A. (2008). The spindle assembly checkpoint. Current Biology, 18(14), R591–R595. https://doi.org/10.1016/j.cub.2008.06.012

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