ST6GALNAC5 expression decreases the interactions between breast cancer cells and the human blood-brain barrier

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Abstract

© 2016 by the authors; licensee MDPI, Basel, Switzerland. The ST6GALNAC5 gene that encodes an α2,6-sialyltransferase involved in the biosynthesis of α-series gangliosides, was previously identified as one of the genes that mediate breast cancer metastasis to the brain. We have shown that the expression of ST6GALNAC5 in MDA-MB-231 breast cancer cells resulted in the expression of G D1α ganglioside at the cell surface. By using a human blood-brain barrier in vitro model recently developed, consisting in CD34 + derived endothelial cells co-cultivated with pericytes, we show that ST6GALNAC5 expression decreased the interactions between the breast cancer cells and the human blood-brain barrier.

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Drolez, A., Vandenhaute, E., Delannoy, C. P., Dewald, J. H., Gosselet, F., Cecchelli, R., … Mysiorek, C. (2016). ST6GALNAC5 expression decreases the interactions between breast cancer cells and the human blood-brain barrier. International Journal of Molecular Sciences, 17(8). https://doi.org/10.3390/ijms17081309

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