The Stromal Niche for Epithelial Stem Cells: A Template for Regeneration and a Brake on Malignancy

17Citations
Citations of this article
70Readers
Mendeley users who have this article in their library.

Abstract

Stromal restraint of cancer growth and progression—emerging as a widespread phenomenon in epithelial cancers such as bladder, pancreas, colon, and prostate—appears rooted in stromal cell niche activity. During normal tissue repair, stromal niche signals, often Hedgehog-induced, promote epithelial stem cell differentiation as well as self-renewal, thus specifying a regenerating epithelial pattern. In the case of cancerous tissue, stromal cell-derived differentiation signals in particular may provide a brake on malignant growth. Understanding and therapeutic harnessing of the role of stroma in cancer restraint may hinge on our knowledge of the signaling programs elaborated by the stromal niche. Stromal restraint of cancer growth and progression—emerging as a widespread phenomenon in epithelial cancers such as bladder, pancreas, colon, and prostate—appears rooted in stromal cell niche activity. During normal tissue repair, stromal niche signals, often Hedgehog-induced, promote epithelial stem cell differentiation as well as self-renewal, thus specifying a regenerating epithelial pattern. In the case of cancerous tissue, stromal cell-derived differentiation signals in particular may provide a brake on malignant growth. Understanding and therapeutic harnessing of the role of stroma in cancer restraint may hinge on our knowledge of the signaling programs elaborated by the stromal niche.

Cite

CITATION STYLE

APA

Roberts, K. J., Kershner, A. M., & Beachy, P. A. (2017, October 9). The Stromal Niche for Epithelial Stem Cells: A Template for Regeneration and a Brake on Malignancy. Cancer Cell. Cell Press. https://doi.org/10.1016/j.ccell.2017.08.007

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free