Stuck in the middle: Drugging the ubiquitin system at the E2 step

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Abstract

The discovery of a small-molecule allosteric inhibitor of the CDC34 ubiquitin-conjugating enzyme (E2) by Ceccarelli et al. raises the possibility that it will be generally feasible to selectively inhibit ubiquitin transfer at this central step in the ubiquitin pathway. © 2011 Elsevier Inc.

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Harper, J. W., & King, R. W. (2011, June 24). Stuck in the middle: Drugging the ubiquitin system at the E2 step. Cell. Cell Press. https://doi.org/10.1016/j.cell.2011.06.002

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