Study of the Molecular Recognition of Aptamers Selected through Ovarian Cancer

88Citations
Citations of this article
94Readers
Mendeley users who have this article in their library.

Abstract

Background: Ovarian cancer is the most lethal gynecological malignancy, and the ovarian clear cell carcinoma subtype (OCCA) demonstrates a particularly poor response to standard treatment. Improvements in ovarian cancer outcomes, especially for OCCA, could be expected from a clearer understanding of the molecular pathology that might guide strategies for earlier diagnosis and more effective treatment. Methodology/Principal Findings: Cell-SELEX technology was employed to develop new molecular probes for ovarian cancer cell surface markers. A total of thirteen aptamers with Kd's to ovarian cancer cells in the pico- to nanomolar range were obtained. Preliminary investigation of the targets of these aptamers and their binding characteristics was also performed. Conclusions/Significance: We have selected a series of aptamers that bind to different types of ovarian cancer, but not cervical cancer. Though binding to other cancer cell lines was observed, these aptamers could lead to identification of biomarkers that are related to cancer. © 2010 Van Simaeys et al.

Cite

CITATION STYLE

APA

van Simaeys, D., Ló pez-Colón, D., Sefah, K., Sutphen, R., Jimenez, E., & Tan, W. (2010). Study of the Molecular Recognition of Aptamers Selected through Ovarian Cancer. PLoS ONE, 5(11). https://doi.org/10.1371/journal.pone.0013770

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free