Moderate to severe chronic graft-versus-host disease (GVHD) is treated with potent immunosuppressive therapy (IST) to modulate the allo-immune response, control symptoms, and prevent further organ damage. We sought to understand the types of treatments used in clinical practice and the likelihood of successful treatment associated with each. A chart review was performed for 250 adult patients at Fred Hutchinson Cancer Research Center enrolled in a prospective observational study. After a median follow-up of 5.6 years for survivors, approximately one-third were still on IST (of whom half were on fourth or greater line of therapy), one-third were alive and off IST, and one-third had relapsed or died. Approximately half of survivors stopped all IST at least once, although half of these restarted IST after a median of 3.4 months (interquartile range, 2.3 to 8.0) off therapy. Successful discontinuation of IST for at least 9 months was associated with myeloablative conditioning (P =.04), more years since transplant (P =.009), and lack of oral (P
CITATION STYLE
Lee, S. J., Nguyen, T. D., Onstad, L., Bar, M., Krakow, E. F., Salit, R. B., … Flowers, M. E. (2018). Success of Immunosuppressive Treatments in Patients with Chronic Graft-versus-Host Disease. Biology of Blood and Marrow Transplantation, 24(3), 555–562. https://doi.org/10.1016/j.bbmt.2017.10.042
Mendeley helps you to discover research relevant for your work.