The explosive growth of the bioinformatics field has led to a large amount of data and software applications publicly available as web resources. However, the lack of persistence of web references is a barrier to a comprehensive shared access. We conducted a study of the current availability and other features of primary bioinformatics web resources (such as software tools and databases). The majority (95%) of the examined bioinformatics web resources were found running on UNIX/Linux operating systems, and the most widely used web server was found to be Apache (or Apache-related products). Of the overall 1,130 Uniform Resource Locators (URLs) examined, 91% were highly available (more than 90% of the time), while only 4% showed low accessibility (less than 50% of the time) during the survey. Furthermore, the most common URL failure modes are presented and analyzed. © 2007 Beijing Genomics Institute.
Thireou, T., Spyrou, G., & Atlamazoglou, V. (2007). A Survey of the Availability of Primary Bioinformatics Web Resources. Genomics, Proteomics and Bioinformatics, 5(1), 70–76. https://doi.org/10.1016/S1672-0229(07)60017-5