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Abstract

Survivin, a member of the inhibitor of apoptosis protein family, has an important role in cell cycle regulation. Insulin-like growth factor-I (IGF-I) is a polypeptide hormone with wide range of biologic effects including stimulation of lipogenesis in sebaceous glands. Their overexpression in some fibrotic disorders suggests a possible implication of both IGF-I and survivin in the pathogenesis of acne and/or acne scars. The current study aimed to assess and correlate serum levels of IGF-I and survivin in patients with active acne vulgaris and postinflammatory acne scars and to evaluate their lesional expressions in comparison to healthy controls. Serum IGF-I and survivin were estimated using commercially available ELISA kits and their tissues expressions were investigated using Western blotting. Our findings suggest that IGF-I and survivin could play potential roles in the pathogenesis of active acne vulgaris and more importantly in postinflammatory acne scars with significant positive correlation coefficient between serum levels of IGF-I and survivin which support IGF-I-/PI3K-/AKT-mediated downregulation of nuclear expression of FoxO transcription factors resulting in enhanced survivin expression.

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H.A., A., W.M., A.-M., B.E.M., E., M.H., H., M.A., A., & S.A., A. (2016). Survivin as a Novel Biomarker in the Pathogenesis of Acne Vulgaris and Its Correlation to Insulin-Like Growth Factor-I. Disease Markers, 2016. https://doi.org/10.1155/2016/7040312 LK  - http://resolver.library.northwestern.edu/nwu?sid=EMBASE&issn=18758630&id=doi:10.1155%2F2016%2F7040312&atitle=Survivin+as+a+Novel+Biomarker+in+the+Pathogenesis+of+Acne+Vulgaris+and+Its+Correlation+to+Insulin-Like+Growth+Factor-I&stitle=Dis.+Markers&title=Disease+Markers&volume=2016&issue=&spage=&epage=&aulast=Assaf&aufirst=Hanan+A.&auinit=H.A.&aufull=Assaf+H.A.&coden=DMARD&isbn=&pages=-&date=2016&auinit1=H&auinitm=A.

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