Syndecan-4 negatively regulates antiviral signalling by mediating RIG-I deubiquitination via CYLD

12Citations
Citations of this article
14Readers
Mendeley users who have this article in their library.

Abstract

Retinoic acid-inducible gene I (RIG-I) plays important roles in pathogen recognition and antiviral signalling transduction. Here we show that syndecan-4 (SDC4) is a RIG-I-interacting partner identified in a yeast two-hybrid screen. We find that SDC4 negatively regulates the RIG-I-mediated antiviral signalling in a feedback-loop control manner. The genetic evidence obtained by using knockout mice further emphasizes this biological role of SDC4 in antiviral signalling. Mechanistically, we show that SDC4 interacts with both RIG-I and deubiquitinase CYLD via its carboxyl-terminal intracellular region. SDC4 likely promotes redistribution of RIG-I and CYLD in a perinuclear pattern post viral infection, and thus enhances the RIG-I-CYLD interaction and potentiates the K63-linked deubiquitination of RIG-I. Collectively, our findings uncover a mechanism by which SDC4 antagonizes the activation of RIG-I in a CYLD-mediated deubiquitination-dependent process, thereby balancing antiviral signalling to avoid deleterious effects on host cells.

Cite

CITATION STYLE

APA

Lin, W., Zhang, J., Lin, H., Li, Z., Sun, X., Xin, D., … Sun, Q. (2016). Syndecan-4 negatively regulates antiviral signalling by mediating RIG-I deubiquitination via CYLD. Nature Communications, 7. https://doi.org/10.1038/ncomms11848

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free