Synergistic effect of lupenone and caryophyllene oxide against Trypanosoma cruzi

Abstract

The in vitro trypanocidal activity of a 1: 4 mixture of lupenone and caryophyllene oxide confirmed a synergistic effect of the terpenoids against epimastigotes forms of T. cruzi (IC50=10.4 g/mL, FIC = 0.46). In addition, testing of the terpenoid mixture for its capacity to reduce the number of amastigote nests in cardiac tissue and skeletal muscle of infected mice showed a reduction of more than 80% at a dose level of 20.8 mg·kg -1·day-1. © 2013 Glendy Polanco- Hernández et al.