In this study we synthesized the new compounds containing bis-1,3,4-thiadiazole 3(A-D)n from many reaction steps (cyclization, diazotization and etherification respectively). The compounds have been characterized by melting point, FT-IR and 1H NMR data. All the synthesized compounds have been evaluated in vitro for their antimicrobial activities against several microbes like: Escherichia coli, Klebsiellia pneumonia, Pseudomonas aeruginosa, Serratia marscens and Staphylococcus aureus and show that some of these compounds have very good antibacterial activity.
Tomi, I. H. R., Al-Daraji, A. H. R., Al-Qaysi, R. R. T., Hasson, M. M., & Al-Dulaimy, K. H. D. (2014). Synthesis, characterization and biological activities of some azo derivatives of aminothiadiazole derived from nicotinic and isonicotinic acids. Arabian Journal of Chemistry, 7(5), 687–694. https://doi.org/10.1016/j.arabjc.2010.12.003