Synthesis and in vitro antibacterial activity of new oxoethylthio-1,3,4-oxadiazole derivatives

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Abstract

In the present investigation, a series of 2(4-pyridyl)-5[(aryl/heteroarylamino)-1-oxoethyl]thio-1,3,4-oxadiazole were synthesized using isonicotinohydrazide and substituted aryl/heteroaryl amines using pyridine as solvent. Newly synthesized compounds were tested for their in vitro anti-tubercular activity against Mycobacterium tuberculosis H37Rv using the BACTEC 460 radiometric system. Among the synthesized compounds, compounds 2(4-pyridyl)-5((2-nitrophenylamino)-1-oxoethyl)thio-1,3,4-oxadiazole (5e), 2(4-pyridyl)-5((4-nitrophenylamino)-1-oxoethyl)thio-1,3,4-oxadiazole (5g) and 2(4-pyridyl)-5((2-pyrrolylamino)-1-oxoethyl)thio-1,3,4-oxadiazole (5k) produced highest efficacy and exhibited. >90% inhibition at a concentration of 0.0077, 0.0052 and 0.0089. μM, respectively. All the new compounds were pharmacologically evaluated for their in vitro Antimicrobial activity. © 2011.

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Raval, J. P., Akhaja, T. N., Jaspara, D. M., Myangar, K. N., & Patel, N. H. (2014). Synthesis and in vitro antibacterial activity of new oxoethylthio-1,3,4-oxadiazole derivatives. Journal of Saudi Chemical Society, 18(2), 101–106. https://doi.org/10.1016/j.jscs.2011.05.019

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