Tangential Networks of Precocious Neurons and Early Axonal Outgrowth in the Embryonic Human Forebrain

  • Bystron I
N/ACitations
Citations of this article
43Readers
Mendeley users who have this article in their library.

Abstract

We used a combination of immunohistochemistry and carbocyanine dye tracing to study neurons and their processes in the human embryonic forebrain, 4-7 weeks after conception, before the onset of synaptogenesis. We discovered a widespread network of precocious MAP2 (microtubule-associated protein 2)-immunoreactive cells, with long, nonaxonal processes, before the appearance of the cortical plate and the establishment of thalamocortical connectivity. Dye tracing revealed that the processes of these precocious cells form tangential links between intermediate zones of the thalamus, ganglionic eminence, hypothalamus, and cortical preplate. The spatiotemporal distribution and morphology of the precocious neurons in the cortical preplate suggest that they are generated outside the cerebral wall rather than in the local ventricular zone. The first thalamocortical axons and axons of preplate cells extend across diencephalo-telencephalic and striatocortical boundaries before the arrival of the first cortical plate neurons. Precocious cells may provide initial communication between subdivisions of the embryonic brain as well as guidance cues for navigation of growing axons and/or transverse neuronal migration.

Cite

CITATION STYLE

APA

Bystron, I. (2005). Tangential Networks of Precocious Neurons and Early Axonal Outgrowth in the Embryonic Human Forebrain. Journal of Neuroscience, 25(11), 2781–2792. https://doi.org/10.1523/jneurosci.4770-04.2005

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free