In a recent issue of Cell, Iliopoulos and colleagues demonstrate a novel and targetable epigenetic amplification loop in hepatocellular carcinoma involving HNF4α, miR-124, IL6-R, Stat3, miR-24, and miR-629. These results establish microRNAs as novel players in early stages of hepatocarcinogenesis and as potential targets for the treatment of hepatocellular carcinoma. © 2011 Elsevier Inc.
Schwabe, R. F., & Wang, T. C. (2011, December 13). Targeting liver cancer: First steps toward a miRacle? Cancer Cell. https://doi.org/10.1016/j.ccr.2011.11.021