Transbilayer (flip-flop) lipid motion and lipid scrambling in membranes

132Citations
Citations of this article
278Readers
Mendeley users who have this article in their library.

Abstract

This paper reviews the current knowledge on the various mechanisms for transbilayer, or flip-flop, lipid motion in model and cell membranes, enzyme-assisted lipid transfer by flippases, floppases and scramblases is briefly discussed, while non-catalyzed lipid flip-flop is reviewed in more detail. Transbilayer lipid motion may occur as a result of the insertion of foreign molecules (detergents, lipids, or even proteins) in one of the membrane leaflets. It may also be the result of the enzymatic generation of lipids, e.g. diacylglycerol or ceramide, at one side of the membrane. Transbilayer motion rates decrease in the order diacylglycerol ≫ ceramide ≫ phospholipids. Ceramide, but not diacylglycerol, can induce transbilayer motion of other lipids, and bilayer scrambling. Transbilayer lipid diffusion and bilayer scrambling are defined as two conceptually and mechanistically different processes. The mechanism of scrambling appears to be related to local instabilities caused by the non-lamellar ceramide molecule, or by other molecules that exhibit a relatively slow flip-flop rate, when asymmetrically inserted or generated in one of the monolayers in a cell or model membrane. © 2009 Federation of European Biochemical Societies.

Cite

CITATION STYLE

APA

Contreras, F. X., Sánchez-Magraner, L., Alonso, A., & Goñi, F. M. (2010, May). Transbilayer (flip-flop) lipid motion and lipid scrambling in membranes. FEBS Letters. https://doi.org/10.1016/j.febslet.2009.12.049

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free