OBJECTIVE: We sought to obtain insight into possible mechanisms underlying preeclampsia using genomewide transcriptional profiling in decidua basalis. STUDY DESIGN: Genomewide transcriptional profiling was performed on decidua basalis tissue from preeclamptic (n = 37) and normal (n = 58) pregnancies. Differentially expressed genes were identified and merged into canonical pathways and networks. RESULTS: Of the 26,504 expressed transcripts detected, 455 were differentially expressed (P < .05; false discovery rate, P < .1). Both novel (ARL5B, SLITRK4) and previously reported preeclampsia-associated (PLA2G7, HMOX1) genes were identified. Pathway analysis revealed that tryptophan metabolism, endoplasmic reticulum stress, linoleic acid metabolism, notch signaling, fatty acid metabolism, arachidonic acid metabolism, and NRF2-mediated oxidative stress response were overrepresented canonical pathways. CONCLUSION: In the present study single genes, canonical pathways, and gene-gene networks that are likely to play an important role in the pathogenesis of preeclampsia have been identified. Future functional studies are needed to accomplish a greater understanding of the mechanisms involved. © 2011 Mosby, Inc.
M., L., S.B., M., M.P., J., M.H., F., K.A., F., I.A., L., … R., A. (2011). A transcriptional profile of the decidua in preeclampsia. American Journal of Obstetrics and Gynecology, 204(1), 84.e1-84.e27. https://doi.org/10.1016/j.ajog.2010.08.043 LK - http://rug.on.worldcat.org/atoztitles/link/?sid=EMBASE&issn=00029378&id=doi:10.1016%2Fj.ajog.2010.08.043&atitle=A+transcriptional+profile+of+the+decidua+in+preeclampsia&stitle=Am.+J.+Obstet.+Gynecol.&title=American+Journal+of+Obstetrics+and+Gynecology&volume=204&issue=1&spage=&epage=&aulast=L%C3%B8set&aufirst=Mari&auinit=M.&aufull=L%C3%B8set+M.&coden=AJOGA&isbn=&pages=-&date=2011&auinit1=M&auinitm=