Trimming Surface Sugars Protects Histoplasma from Immune Attack

  • Brown G
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Abstract

Dectin-1 is an essential innate immune receptor that recognizes β-glucans in fungal cell walls. Its importance is underscored by the mechanisms that fungal pathogens have evolved to avoid detection by this receptor. One such pathogen is Histoplasma capsulatum , and in a recent article in mBio , Rappleye’s group presented data showing that yeasts of this organism secrete a β-glucanase, Eng1, which acts to prune β-glucans that are exposed on the fungal cell surface [A. L. Garfoot et al., mBio 7(2):e01388-15, 2016, http://dx.doi.org/10.1128/mBio.01388-15 ]. The trimming of these sugars reduces immune recognition through Dectin-1 and subsequent inflammatory responses, enhancing the pathogenesis of H. capsulatum .

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Brown, G. D. (2016). Trimming Surface Sugars Protects Histoplasma from Immune Attack . MBio, 7(2). https://doi.org/10.1128/mbio.00553-16

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