TRAIL/Apo-2L induces rapid apoptosis of a variety of tumor cell lines. A family of tumor necrosis factor receptor-related molecules have been identified as receptors for TRAIL. Herein, we report the identification of another member of the TRAIL receptor family, TRUNDD (TRAIL receptor with a truncated death domain). The TRUNDD transcript was detected in multiple human tissues. TRUNDD is highly homologous to all known TRAIL receptors and has an extracellular TRAIL-binding domain but lacks a functional intracellular death domain and does not induce apoptosis. Consistent with an inhibitory role, ectopic expression of TRUNDD attenuated TRAIL-induced apoptosis in mammalian cells.
Pan, G., Ni, J., Yu, G. L., Wei, Y. F., & Dixit, V. M. (1998). TRUNDD, a new member of thr TRAIL receptor family that antagonizes TRAIL signalling. FEBS Letters, 424(1–2), 41–45. https://doi.org/10.1016/S0014-5793(98)00135-5