How vaccinia virus has evolved to subvert the host immune response

Citations of this article
Mendeley users who have this article in their library.


Viruses are obligate intracellular parasites and are some of the most rapidly evolving and diverse pathogens encountered by the host immune system. Large complicated viruses, such as poxviruses, have evolved a plethora of proteins to disrupt host immune signalling in their battle against immune surveillance. Recent X-ray crystallographic analysis of these viral immunomodulators has helped form an emerging picture of the molecular details of virus-host interactions. In this review we consider some of these immune evasion strategies as they apply to poxviruses, from a structural perspective, with specific examples from the European SPINE2-Complexes initiative. Structures of poxvirus immunomodulators reveal the capacity of viruses to mimic and compete against the host immune system, using a diverse range of structural folds that are unique or acquired from their hosts with both enhanced and unexpectedly divergent functions. © 2011 Elsevier Inc.




Bahar, M. W., Graham, S. C., Chen, R. A. J., Cooray, S., Smith, G. L., Stuart, D. I., & Grimes, J. M. (2011, August). How vaccinia virus has evolved to subvert the host immune response. Journal of Structural Biology.

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free