Background: In the last decade, childhood neurological disorders involving inadequate transport of thiamine, riboflavin or folates into brain have been defined. These involve two transporters of folate (the folate receptor α or the proton-coupled folate transporter), one of thiamine and two of the six riboflavin transporters. Depending on the mutations involved, without a specific diagnosis and treatment, the phenotypes vary from mild to severe and fatal.
Spector, R. (2014). Vitamin Transport Diseases of Brain: Focus on Folates, Thiamine and Riboflavin. Brain Disorders & Therapy, 03(02). https://doi.org/10.4172/2168-975x.1000120