Zonisamide for seizures in Parkinson's disease with dementia

  • Tombini M
  • Pellegrino G
  • Di Pino G
  • et al.
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Presents a case report of a 78 year old male diagnosed with Parkinson's disease (PD) ten years before his presentation with seizures. At first, he had complained of resting tremor of the right hand, but later he had gradually worsening extrapyramidal symptoms with bradykinesia, dysarthria, hypomimia, hyposmia and a camptocormic posture when walking. He was initially treated with pramipexole. After one year levodopa was added and gradually increased to a dosage of without fully controlling his PD symptoms. Neurological examination on admission to our department showed a mild-to-moderate extrapyramidal syndrome. After the evaluation ZNS was added to the previously prescribed antiparkinsonian medication. At one-month follow-up the patient was seizure-free without any adverse effects and demonstrated a clear improvement of his extrapyramidal symptoms on neurological examination, especially in terms of tremor and bradykinesia. The improvement was clinically significant: the patient regained his independence in everyday life and recovered his interests, such as cycling and gardening; his mood also improved. This improvement was maintained at six months and one-year follow-up without any changes of his anti-PD drugs. The patient's cognitive status also remained stable. In conclusion, it propose that low dose ZNS could be an optimal and well-tolerated choice for the treatment of seizures in patients affected by PD. (PsycINFO Database Record (c) 2013 APA, all rights reserved)




Tombini, M., Pellegrino, G., Di Pino, G., & Assenza, G. (2013). Zonisamide for seizures in Parkinson’s disease with dementia. Seizure, 22(4), 324–325. https://doi.org/10.1016/j.seizure.2013.01.011

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