99mTc-Ti-DTPA: Preparation, control and biological distribution

  • Vilček Š
  • Macháň V
  • Kalinčák M
 et al. 
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Abstract

A new method is described for the preparation of a DTPA complex containing99mTc using an acidic solution of TiCl3as a reducing agent. Paper chromatography has confirmed that the99mTi-DTPA preparation contained at least 2% of free pertechnetate immediately after preparation. This preparation is suitable for biological application within 2 h after preparation if stored at room temperature, and within 4 h if stored at reduced temperature (+4°C). The biological distribution in rats indicated that the preparation was readily removed from the organism with slight accumulation of activity in the kidneys and in bone. © 1979.

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Authors

  • Štefan Vilček

  • Vladimír Macháň

  • Miroslav Kalinčák

  • Andrej Nicák

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