99mTc-Ti-DTPA: Preparation, control and biological distribution

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Abstract

A new method is described for the preparation of a DTPA complex containing 99mTc using an acidic solution of TiCl3 as a reducing agent. Paper chromatography has confirmed that the 99mTi-DTPA preparation contained at least 2% of free pertechnetate immediately after preparation. This preparation is suitable for biological application within 2 h after preparation if stored at room temperature, and within 4 h if stored at reduced temperature (+4°C). The biological distribution in rats indicated that the preparation was readily removed from the organism with slight accumulation of activity in the kidneys and in bone. © 1979.

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Vilček, Š., Macháň, V., Kalinčák, M., & Nicák, A. (1979). 99mTc-Ti-DTPA: Preparation, control and biological distribution. The International Journal Of Applied Radiation And Isotopes, 30(11), 673–676. https://doi.org/10.1016/0020-708X(79)90108-X

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