The acid-base equilibria of a series of benzodiazepines in acetonitrile have been studied, and pKHB+values determined. The theory of such titrations is discussed and simple potentiometric and visual methods in acetonitrile media are proposed for the assay of benzodiazepines in pharmaceutical formulations. © 1989.
Barbosa, J., & Sanz-Nebot, V. (1989). Acid-base equilibria and assay of benzodiazepines in acetonitrile medium. Talanta, 36(8), 837–842. https://doi.org/10.1016/0039-9140(89)80164-X