Acid-base equilibria and assay of benzodiazepines in acetonitrile medium

  • Barbosa J
  • Sanz-Nebot V
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Abstract

The acid-base equilibria of a series of benzodiazepines in acetonitrile have been studied, and pKHB+values determined. The theory of such titrations is discussed and simple potentiometric and visual methods in acetonitrile media are proposed for the assay of benzodiazepines in pharmaceutical formulations. © 1989.

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