Amino acid antagonists do not block the depolarizing effects of potassium ions on frog primary afferents

  • Davidoff R
  • Hackman J
  • Osorio I
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Abstract

The effects of picrotoxin, bicuculline and strychnine on the dorsal root potential evoked by dorsal root stimulation and on the responses of primary afferents to elevated [K+] and to γ-aminobutyric acid (and in some cases to β-alanine) were studied by sucrose gap recording from dorsal roots of the isolated hemisected frog spinal cord. Bicuculline and picrotoxin when applied in concentrations sufficient to block depolarizations of dorsal roots evoked by γ-aminobutyrate and the early phase (initial 150-200 ms) of the dorsal root potential did not alter the sensitivity of primary afferents to the depolarizing effects of K+. Strychnine produced inconsistent effects on the early component of the dorsal root potential, but in low or moderate concentrations (

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Authors

  • R. A. Davidoff

  • J. C. Hackman

  • I. Osorio

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