Analytical method used for PIXE analyses

Abstract

Some metallic prostheses undergo physico-chemical modifications a few years after their implantation. The organism reaction leads to a corrosion process. Consequently, liberation of metallic debris or wear might be observed. The purpose of our analysis was to determine the importance, in surrounding tissues, of the contamination by metallic elements released from joint prosthesis and to localise it. We analysed two types of samples: the first ones were taken during surgical procedure and the other ones were extracted in post-mortem tissues. PIXE technique (Particles Induced X-ray Emission) with a 50 μm proton beam and 3 MeV of energy is an efficient technique to analyse these tissues. We used it to determine qualitatively and quantitatively trace element contamination, and we have developed an analytical method based on the χ2 distribution to separate the different contributions of the different elements, to detect the possible correlation between these metallic elements. © 2005 Elsevier B.V. All rights reserved.