Anthranilamide inhibitors of factor Xa

  • Mendel D
  • Marquart A
  • Joseph S
 et al. 
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Abstract

SAR about the B-ring of a series of N2-aroyl anthranilamide factor Xa (fXa) inhibitors is described. B-ring o-aminoalkylether and B-ring p-amine probes of the S1′ and S4 sites, respectively, afforded picomolar fXa inhibitors that performed well in in vitro anticoagulation assays. © 2007 Elsevier Ltd. All rights reserved.

Author-supplied keywords

  • Anticoagulant
  • Factor Xa
  • Protease inhibitor

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Authors

  • David Mendel

  • Angela L. Marquart

  • Sajan Joseph

  • Philip Waid

  • Ying K. Yee

  • Anne Louise Tebbe

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