The expression of phosphorylated extracellular signal-regulated kinase 1/2 (pERK 1/2) was evaluated in the vestibular nuclei (VN) of rats following unilateral labyrinthectomy (UL). Immunohistochemistry revealed a significant asymmetrical increase in pERK 1/2 expression in the VN, 5 min after UL, after which pERK 1/2 immunoreactivity decreased rapidly and was undetectable by 90 min after UL. These results suggest that unilateral deafferentation of the vestibular system triggers intracellular signal pathways that activate ERK 1/2 in the VN. © 2004 Elsevier B.V. All rigths reserved.
Kim, M. S., Choi, M. A., Choi, D. O., Lee, M. Y., Kim, K. Y., Rhee, J. K., … Park, B. R. (2004). Asymmetric activation of extracellular signal-regulated kinase 1/2 in rat vestibular nuclei by unilateral labyrinthectomy. Brain Research, 1011(2), 238–242. https://doi.org/10.1016/j.brainres.2004.03.031