Asymmetric activation of extracellular signal-regulated kinase 1/2 in rat vestibular nuclei by unilateral labyrinthectomy

  • Kim M
  • Choi M
  • Choi D
 et al. 
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Abstract

The expression of phosphorylated extracellular signal-regulated kinase 1/2 (pERK 1/2) was evaluated in the vestibular nuclei (VN) of rats following unilateral labyrinthectomy (UL). Immunohistochemistry revealed a significant asymmetrical increase in pERK 1/2 expression in the VN, 5 min after UL, after which pERK 1/2 immunoreactivity decreased rapidly and was undetectable by 90 min after UL. These results suggest that unilateral deafferentation of the vestibular system triggers intracellular signal pathways that activate ERK 1/2 in the VN. © 2004 Elsevier B.V. All rigths reserved.

Author-supplied keywords

  • Extracellular signal-regulated kinase
  • Motor systems and sensorimotor integration
  • Unilateral labyrinthectomy
  • Vestibular compensation
  • Vestibular nucleus
  • Vestibular system

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Authors

  • Min Sun Kim

  • Myoung Ae Choi

  • Dong Ok Choi

  • Moon Young Lee

  • Kwang Yong Kim

  • Jeong Kyun Rhee

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