Asymmetric alkylation of glycine imine esters using solid supports preloaded with base

Abstract

Investigations into the use of solid supports preloaded with base for the asymmetric alkylation of a benzophenone-derived glycine-imine was described. Residual traces of water on the support dramatically accelerated the reactions to complete within a few minutes. The conditions employed in the present synthesis are mild, efficient and general. Graphical Abstract. © 2004 Elsevier Ltd. All rights reserved.