Asymmetric alkylation of glycine imine esters using solid supports preloaded with base

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Abstract

Investigations into the use of solid supports preloaded with base for the asymmetric alkylation of a benzophenone-derived glycine-imine was described. Residual traces of water on the support dramatically accelerated the reactions to complete within a few minutes. The conditions employed in the present synthesis are mild, efficient and general. Graphical Abstract. © 2004 Elsevier Ltd. All rights reserved.

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Yu, H., Takigawa, S., & Koshima, H. (2004). Asymmetric alkylation of glycine imine esters using solid supports preloaded with base. Tetrahedron, 60(38), 8405–8410. https://doi.org/10.1016/j.tet.2004.07.002

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