Asymmetric alkylation of glycine imine esters using solid supports preloaded with base

  • Yu H
  • Takigawa S
  • Koshima H
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Abstract

Investigations into the use of solid supports preloaded with base for the asymmetric alkylation of a benzophenone-derived glycine-imine was described. Residual traces of water on the support dramatically accelerated the reactions to complete within a few minutes. The conditions employed in the present synthesis are mild, efficient and general. Graphical Abstract. © 2004 Elsevier Ltd. All rights reserved.

Author-supplied keywords

  • Amino acids
  • Asymmetric alkylation
  • Chiral phase transfer catalysts
  • Glycine imine esters
  • Solid supports

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Authors

  • Haitao Yu

  • Setsuko Takigawa

  • Hideko Koshima

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