Blood concentration and turnover of circulating mevalonate in the rat

  • Hagenfeldt L
  • Hellström K
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Abstract

A technique was developed for measuring mevalonate by gas chromatography using a mass spectrometer as a specific detector. The concentration of mevalonate in rat blood was found to be 0.02 to 0.04 μg/ml. After the intravenous injection of (1-14C) acetate to rats, the blood contained labelled material tentatively identified as mevalonate. The half-life of this material averaged 7.4 min. The data indicate that the contribution of circulating mevalonate to cholesterol synthesis in the rat could be at most about 2 percent. In cholesterol-fed rats the blood concentration of mevalonate was lower (

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Authors

  • Lars Hagenfeldt

  • Kjell Hellström

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