Conditioned saccharin taste aversion induced by mycotoxins in rats: Lack of effect of ochratoxin A

  • Clark D
  • Wellman P
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Abstract

The present study examined the putative aversive action of ochratoxin A (OA) using a conditioned saccharin aversion paradigm. Adult male rats consumed a 0.1% saccharin solution then were treated (IP) with either a 5% NaHCO3vehicle (negative control), 32 mg/kg LiCl (positive control) or 0.75, 1.5 or 3.0 mg/kg OA. Twenty-four hours later, the rats were given a choice between tap water and the 0.1% saccharin solution. Rats treated with the vehicle or any of the doses of OA exhibited a marked preference for the saccharin solution, whereas the rats treated with LiCl exhibited a marked rejection of the saccharin solution. The implications of these data for an understanding of mycotoxicosis are discussed. © 1989.

Author-supplied keywords

  • Anorexia
  • Behavioral toxicity
  • Conditioned saccharin aversion
  • Feed refusal
  • Mycotoxins
  • Ochratoxin A
  • Rats
  • Taste aversion

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Authors

  • Donald E. Clark

  • Paul J. Wellman

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