Crystallisation induced asymmetric transformation (CIAT) in the synthesis of furoylalanines and furylcarbinols

  • Jakubec P
  • Berkeš D
  • Šiška R
 et al. 
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A new synthesis of enantiomerically highly enriched N-substituted furoylalanines has been developed. This process involves the combination of crystallisation induced asymmetric transformation (CIAT) and a conjugate addition of N-nucleophiles to furoylacrylic acids. Further transformations to furoylalanines and substituted furylcarbinols are also described. © 2006 Elsevier Ltd. All rights reserved.

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  • Pavol Jakubec

  • Dušan Berkeš

  • Richard Šiška

  • Mária Gardianová

  • František Považanec

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