Determination of (fluoro)quinolone antibiotic residues in pig kidney using liquid chromatography-tandem mass spectrometry: I. Laboratory-validated method

  • Toussaint B
  • Chedin M
  • Bordin G
 et al. 
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Abstract

A new LC-MS/MS method has been developed for the multiresidue determination of 11 (fluoro)quinolone antibiotics (FQs), including acidic and amphoteric species, around their maximum residue level (MRL) in pig kidney. The procedure involves a common sample preparation by solid-phase extraction on disposable extraction cartridges followed by a fast reversed-phase liquid chromatography-tandem mass spectrometry analysis. The method was validated according to the Commission Decision 2002/657/CE. The accuracy of the method was satisfactory with recoveries included in the interval 80-100%. The precision results showed mean repeatability and reproducibility coefficients of 7.4% and 11.8%, respectively. Limits of quantification much lower than the MRLs could be obtained. © 2005 Elsevier B.V. All rights reserved.

Author-supplied keywords

  • Fluoroquinolone
  • Liquid chromatography-tandem mass spectrometry
  • Pig kidney
  • Validation

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Authors

  • B. Toussaint

  • M. Chedin

  • G. Bordin

  • A. R. Rodriguez

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