Determination of isometamidium residues in animal-derived foods by liquid chromatography-tandem mass spectrometry

  • Li Y
  • Zou Y
  • Zhang L
 et al. 
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Abstract

In this paper, a new determination method for isometamidium residues in animal-derived foods was developed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Isometamidium residues in bovine tissues and milk were extracted with the mixed solution of acetonitrile and 0.25. mol/L of ammonium formate-methanol (v/v, 1:1), concentrated and degreased, and determined by LC-MS/MS with quantification by external standard method. The results showed that the peak area of chromatogram was linearly related to the concentration of isometamidium in the range of 1-100 μg/L, and the limits of detection (LOD) and quantification (LOQ) were 0.05 μg/kg and 5 μg/kg, respectively. The average recoveries of spiked samples were in the range of 73.8-93.9% with relative standard deviations ranged from 2.3% to 7.5%. This method is simple, accurate and suitable for the identification and quantification for isometamidium in animal-derived foods. © 2011 Elsevier B.V.

Author-supplied keywords

  • Animal-derived food
  • HPLC-MS/MS
  • Isometamidium
  • Residual detection

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Authors

  • Y. G. Li

  • Y. Zou

  • L. Zhang

  • C. X. Xi

  • G. M. Wang

  • X. L. Li

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