A new method for the preparation of enantiomerically pure N-benzyl nitrones is described. By using either a one-pot reduction-transimination or a one-pot Grignard addition-transimination sequence chiral O-protected α-hydroxynitriles can be converted into chiral aldo- and ketonitrones, respectively.
Hulsbos, E., Marcus, J., Brussee, J., & Van der Gen, A. (1997). Direct conversion of chiral cyanohydrins to chiral nitrones by transimination. Tetrahedron Asymmetry, 8(7), 1061–1067. https://doi.org/10.1016/S0957-4166(97)00066-9