Discovery and SAR of diarylsulfide cyclopropylamide LFA-1/ICAM-1 interaction antagonists

  • Link J
  • Sorensen B
  • Liu G
 et al. 
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Abstract

Diarylsulfide cyclopropylamides were synthesized and evaluated as LFA-1/ICAM-1 interaction antagonists. A substituent pattern was identified which maximized potency and minimized protein binding as exemplified by antagonist 30 (IC50= 5 nM). © 2001 Elsevier Science Ltd.

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Authors

  • James T. Link

  • Bryan Sorensen

  • Gang Liu

  • Zhonghua Pei

  • Edward B. Reilly

  • Sandra Leitza

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