Dorsal horn opiate administration attenuates the perceived intensity of noxious heat stimulation in behaving monkey

  • Oliveras J
  • Maixner W
  • Dubner R
 et al. 
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Abstract

In monkeys trained to detect and discriminate noxious heat stimuli, morphine microinjected into the medullary dorsal horn attenuated the perceived intensity of noxious heat in a dose- and stimulus-dependent fashion. These data demonstrate a pharmacologically specific effect of opiates on the sensory intensity component of pain at the earliest central relay pathway transmitting noxious information. © 1986.

Author-supplied keywords

  • dorsal horn
  • noxious heat
  • opiate
  • pain
  • perceived intensity

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