Dual 24-hour feeding response to 2DG in rats: Daytime increase and nighttime decrease

10Citations
Citations of this article
4Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Thirty-six rats were injected IP with 2DG (0, 250, or 500 mg/kg) at 7-day intervals, once at light onset (7 a.m.) and once at dark onset (7 p.m.), and postinjection food intake was monitored for 24 hours. Five hundred mg/kg 2DG caused food intake to rise above control levels during the first 6 hours of daylight, regardless of whether the injection had occurred that morning or the previous evening, whereas intake during the first 6 hours of darkness was consistently below control levels. In a second study, 24 rats were injected first at 7 a.m. (500 mg/kg 2DG or saline), and 7 days later at 7 p.m. (opposite drug), and food was withheld 12 hours until the light:dark period had changed. For 12 hours after food was returned, 2DG again decreased nighttime food intake (Injection 1) and increased daytime intake (Injection 2). 2DG's dual long-term effects cannot be accounted for either by malaise or by an initial action that later is compensated by its opposite. Rather, 2DG (500 mg/kg) appears to exert two independent, opposite alimentary effects which persist 18-24 hours and which change direction with phase changes in the light:dark cycle. © 1989.

Cite

CITATION STYLE

APA

Thompson, C. I., Fleming, R. L., Franken, K. A., Hornback, D. A., & Boha, S. P. (1989). Dual 24-hour feeding response to 2DG in rats: Daytime increase and nighttime decrease. Physiology and Behavior, 45(1), 155–161. https://doi.org/10.1016/0031-9384(89)90179-0

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free