Effects of acute methamphetamine administration on spacing in paired rats: Investigation with an automated video-analysis method

  • Shinba T
  • Yamamoto K
  • Cao G
 et al. 
  • 5


    Mendeley users who have this article in their library.
  • 15


    Citations of this article.


Effects of acute methamphetamine administration on spacing and locomotor activity were investigated in paired rats using a computer-assisted automated video-analysis method. Both 0.1 and 1 mg/kg of methamphetamine significantly increased the spacing in comparison with saline. This alteration in behavioral interaction by methamphetamine may serve as one of the animal models of social withdrawal. A significant increase in locomotor activity was found after 1 mg/kg of methamphetamine. 0.1 mg/kg dosage was accompanied by a locomotor change of a lesser degree and shorter duration. The difference with respect to the dose dependency and the time course indicates that the changes in these two behavioral indices by methamphetamine may have different underlying mechanisms.

Author-supplied keywords

  • locomotor activity
  • methamphetamine
  • rat
  • social behavior
  • social withdrawal
  • spacing
  • video-analysis

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free