Evidence for serotonin sensitivity of adult rat spinal axons: Studies using randomized double pulse stimulation

  • Saruhashi Y
  • Young W
  • Sugimori M
 et al. 
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Abstract

We have recently shown both inhibitory and excitatory effects of serotonin on neonatal rat dorsal column axons. While neonatal rat dorsal column axons also respond to norepinephrine and GABA, adult rat dorsal columns are insensitive to the actions of both compounds. Therefore, we studied the effects of serotonin agonists on adult rat dorsal column axons using randomized double pulse stimuli at 0.2 Hz with random interpulse intervals of 3, 4, 5, 8, 10, 20, 30, 50 and 80 ms. The serotonin(1A) agonist, 8-hydroxy-dipropylaminotetralin-hydrobromide (8-OH-DPAT), significantly modulated test response amplitudes at 3, 4, 5 and 8 ms interpulse intervals by 29.6±4.0%, 17.4±2.1%, 9.6±2.3%, and 12.4±2.2% of conditioning pulse amplitudes, respectively. The mean latencies at 3, 4 and 5 ms interpulse intervals increased by 17.0±5.1%, 8.6±2.1%, and 5.1±1.4%, respectively (P

Author-supplied keywords

  • 5-HT(1A)
  • 5-HT2A
  • 5-hydroxytryptamine (5-HT)
  • Adult dorsal column
  • Randomized double pulse

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Authors

  • Y. Saruhashi

  • W. Young

  • M. Sugimori

  • J. Abrahams

  • J. Sakuma

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