The excitatory response of the adrenal sympathetic nerve to severe hypoxia decreases in aged rats

  • Sato A
  • Trzebski A
  • 5

    Readers

    Mendeley users who have this article in their library.
  • 7

    Citations

    Citations of this article.

Abstract

The age-related changes in the sensitivity of the adrenal sympathetic nerve to hypoxia were investigated in anesthetized young adult (3-4 months old) and aged rats (25-26 months old). Hypoxia with end-tidal O2concentration FETO2) at 6-2% caused excitation of adrenal nerve activity in the young adult and the aged rats. There was a significant decrease in the responses at 3 and 2% FETO2in the aged rats compared to the young adult rats at either peripheral chemoreceptors-intact or -denervated condition. Reduced responsiveness of the central chemoreceptors to severe hypoxia is suggested as a possible factor in the age-related decreases. © 1993.

Author-supplied keywords

  • Adrenal sympathetic nerve
  • Aging
  • Carotid sinus nerve
  • Central and peripheral chemoreceptor
  • Hypoxia
  • Rat
  • Vago-depressor nerve

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Akio Sato

  • Andrzej Trzebski

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free