To quantitate accurately impurities such as crystn. solvents, isomers, or other residual substances in chem. raw materials, the effect of the matrix on those residuals must be accounted for. The criteria for evaluation of matrix effects on gas chromatog. quantitation of some residual compds. are described. Typical method development including sample handling, linearity and precision evaluations, and a practical approach to the decision as to whether std. addn. is necessary, is described.
Souter, R. W. (1980). Gas chromatographic quantitation of residual impurities in raw material matrixes. Journal of Chromatography, 193(2), 207–212.