To quantitate accurately impurities such as crystallization solvents, isomers, or other residual substances in chemical raw materials, the effect of the matrix on those residuals must be accounted for. This paper describes criteria for evaluation of matrix effects on gas chromatographic quantitation of some residual compounds. Typical method development including sample handling, linearity and precision evaluations, and a practical approach to the decision as to whether standard addition is necessary, is described. © 1980.
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